Cognomen Aquino Santana (Aquino Santana 
) , in the world, is a very rare family name. The family name Aquino Santana is characteristic of Latin America and the Caribbean, particularly the Dominican Republic, where it is a rare surname, Uruguay, and Ecuador, where it is a very rare surname.
| VARIANT | COUNTRY |
|---|---|
| Aquino Santana | Chile, Dominican Republic, Uruguay, Ecuador |