Surname איסאייס (Isaias 
, Issaias 
, איסאייס 
) , globally, is a widespread family name. The surname איסאייס is habitual in Latin America and the Caribbean, particularly Mexico, where it is quite a common surname, Nicaragua, and Honduras (explore the name in all countries). Not in comparison with a country's population, it is commonest in Mexico, Spain, and Brazil. More frequently, איסאייס is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Isaias | Peru, Philippines, Brazil, Mexico, Guatemala |
| Issaias | Peru, Brazil, United States, Mexico, Honduras |
| איסאייס | Israel |