Last name Шпильрайн (Шпильрайн 
) , globally, is a very rare family name. The last name Шпильрайн is habitual in Eastern Europe, particularly Russia, where it is a very rare surname.
| шпильрайн, эмиль николаевич Soviet biologist, RU (b. 1899) |
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| шпильрайн, эвальд эмильевич Soviet physicist (1926-2009), RU (b. 1926) |
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