Surname Деспотовић (Деспотовић 
) , in all the world, is a rare cognomen. The last name Деспотовић is characteristic of Southern Europe, particularly Serbia, where it is quite a rare surname.
| милета деспотовић RS (b. 1822) |
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јован деспотовић Serbian art historian, RS (b. 1952) |
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| александар аца деспотовић Serbian writer (1933-2009), RS (b. 1933) |
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иван деспотовић (b. 1978) |
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ђорђе деспотовић footballer, RS (b. 1992) |
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| весна деспотовић Olympic medalist in basketball, RS (b. 1961) |
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| ранко деспотовић Serbian association football player, RS (b. 1983) |
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