Globally, Santa Irene (Santa Irene 
) is a rare feminine forename. The first name Santa Irene is habitual in Latin America and the Caribbean, particularly the Dominican Republic, where it is a rare female name, Argentina, and Peru. In absolute terms, this name is the most popular in Latin America and the Caribbean, particularly Mexico, Argentina, and Peru. Much less frequently, Santa Irene is the last name as well as the forename.
| VARIANT | COUNTRY |
|---|---|
| Santa Irene | Peru, Argentina, Dominican Republic, Mexico, Ecuador |