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All around the world, בריין (Brain , Brienne , Braine ) is quite a common dominantly boy's, but infrequently female given name. The given name בריין is characteristic of Sub-Saharan Africa, particularly Namibia, where it is quite a rare masculine name, South Africa, and Ghana. In absolute terms, it is commonest in the United States, South Africa, and Indonesia. Also, בריין is the last name as well as the forename.
בריין is also a name for the fictitious and mythical characters: Brienne of Tarth , the character in George R. R. Martin's A Song of Ice and Fire series, Game of Thrones; Brain , the main character of Pinky and the Brain, Animaniacs; Brain , the fictional dog from Inspector Gadget; Brain , the Fictional supervillain in DC Comics and Brain , the Top Cat character, among other works.