Surname Opiyo (Opiyo 
) , globally, is a common family name. The surname Opiyo is characteristic of Sub-Saharan Africa, particularly Kenya, where it is quite a common surname, Botswana, where it is quite a rare surname, and Uganda. Not in comparison with a country's population, it is commonest in Sub-Saharan Africa, particularly Kenya, Uganda, and Tanzania. Very seldom, Opiyo is the forename as well as the last name.
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| Opiyo | Botswana, Uganda, Kenya, Ethiopia, Tanzania |
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nicholas opiyo human rights activist in Uganda, UG |
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peter opiyo Kenyan footballer, KE (b. 1992) |
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| opiyo oloya Ugandan-Canadian educator and author, UG (b. 1958) |
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| opiyo okach Kenyan dancer and choreographer, KE (b. 1963) |
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| philip opiyo Kenyan footballer, KE (b. 1979) |
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| mary a opiyo researcher (ORCID 0000-0001-9660-5888) |
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| george opiyo reseacher in New Zealand |
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| nicholas opiyo Ugandan human rights lawyer |
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| nicholas opiyo researcher ORCID ID = 0000-0002-9666-8712 |
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| opiyo ododa retired Kenyan Lt Colonel now with African Union, KE |
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| opiyo okeyo Kenyan-American filmmaker, KE |
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| rose okoyo opiyo researcher |
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| jared odhiambo opiyo Kenyan politician |
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| maureen otienu opiyo |
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| levis opiyo Kenyan footballer, KE (b. 1995) |
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