Family name Mtshali (Mtshali 
) , in the world, is a common cognomen. The last name Mtshali is characteristic of South Africa, where it is quite a common surname, Eswatini, and Australia, where it is a rare surname. Measured by absolute frequency, this name is the most popular in South Africa, Eswatini, and the United Kingdom.
| VARIANT | COUNTRY |
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| Mtshali | Eswatini, United Kingdom, Australia, South Africa, United States |
| oswald mbuyiseni mtshali South African poet, ZA (b. 1940) |
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| thembi mtshali South African actor, ZA (b. 1949) |
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| thembi mtshali South African actress (b. 1949) |
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| lionel mtshali South African politician, ZA |
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| sifiso mtshali researcher |
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| pinkie mtshali South African performing artist, ZA |
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| senzo mtshali researcher |
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| s'dumo mtshali South African actor, ZA (b. 1983) |
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| ayanda mtshali football player (b. 1988) |
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| lehlohonolo mtshali football player (b. 1994) |
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