Cognomen Mthethwa (Mthethwa 
) , across the world, is a common last name. The cognomen Mthethwa is habitual in Sub-Saharan Africa, particularly Eswatini, where it is a common surname, South Africa, where it is quite a common surname, and Botswana, where it is quite a rare surname. Not in comparison with a country's population, it most frequently occurs in Sub-Saharan Africa, particularly South Africa, Eswatini, and Zimbabwe.
| VARIANT | COUNTRY |
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| Mthethwa | Eswatini, Zimbabwe, Botswana, United Kingdom, South Africa |
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nathi mthethwa South African politician, ZA (b. 1967) |
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khaya mthethwa South African singer, ZA (b. 1987) |
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| zwelethu mthethwa South African artist, ZA (b. 1960) |
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| mxolisi mthethwa Swazi footballer, SZ (b. 1978) |
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| jabulile mthethwa researcher |
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| nomfundo mthethwa researcher |
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| ndoda mthethwa Swazi footballer, SZ (b. 1987) |
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| minenhle mthethwa South African rugby union footballer (1991-), ZA (b. 1991) |
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| sibusiso mthethwa South African soccer player (b. 1991) |
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| sandile mthethwa South African soccer player, ZA (b. 1997) |
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