Last name Mphahlele (Mphahlele 
) , in the entire world, is a common family name. The cognomen Mphahlele is characteristic of South Africa, where it is quite a common surname, Lesotho, where it is quite a rare surname, and Ireland, where it is a rare surname. In absolute terms, it is commonest in South Africa, Lesotho, and the United States. Much less frequently, Mphahlele is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Mphahlele | United Kingdom, South Africa, Lesotho, Australia, United States |
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es'kia mphahlele South African writer and publisher, ZA (b. 1919) |
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| malose jack mphahlele researcher |
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| rebogile mphahlele researcher ORCID id 0000-0001-9350-554X |
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| maphahlaganye j mphahlele researcher |
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| jeffrey mphahlele |
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| ramahlwe mphahlele South African association football player, ZA (b. 1990) |
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| ryan mphahlele South African long-distance runner (b. 1998) |
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