Surname Mastaglio (Mastaglio 
) , globally, is a rare family name. The cognomen Mastaglio is habitual in Latvia, where it is a rare surname, Italy, and Argentina. Measured by absolute frequency, it is the most numerous in Italy, Argentina, and the United States.
| VARIANT | COUNTRY |
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| Mastaglio | United Kingdom, Italy, Switzerland, United States, Argentina |
| domenico mastaglio German painter, DE (b. 1851) |
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| claudio mastaglio researcher |
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| jamie mastaglio college basketball player (1995–1998) Princeton |
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Mr, Scott, Ailen, Chris, Chloe, Carlo, Brian, Karen, Paula, Paolo, Perry, Peter, Ruben, David, Diane, Linda, Loris, Luisa, Lydia, James, Julio, Tanya, Sarah, Mauro, Marco, Martu, Don, Mary, Mark, Matt, Sara, Anna, Carl, Kurt, Dave, Lana, Tyler, Leah, Luis, Luke, Jose, Josh, Jeni, Juan, Judy, Noah, Maria, Mario, Luca, and Noemi