Last name Lesaffre (Lesaffre 
) , in the world, is quite a rare family name. The cognomen Lesaffre is characteristic of France, where it is quite a rare surname, Belgium, and Australia, where it is a very rare surname. In absolute terms, it is commonest in France, Belgium, and the United States.
| VARIANT | COUNTRY |
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| Lesaffre | Australia, France, Poland, United States, Belgium |
| françois lesaffre Belgian politician, BE (b. 1763) |
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| ernest lesaffre French politician, FR (b. 1837) |
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| jan-baptist lesaffre (b. 1864) |
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roland lesaffre French actor, FR (b. 1927) |
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| jean-loup lesaffre French politician, FR (b. 1938) |
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fantine lesaffre French swimmer, FR (b. 1994) |
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sofia lesaffre French actress, FR (b. 1997) |
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| guilhem lesaffre French ornithologist, teacher and writer, FR (b. 1954) |
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| benoît lesaffre FR (b. 1952) |
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| bruno lesaffre French swimmer, FR (b. 1962) |
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| elodie lesaffre French sailor, FR (b. 1979) |
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| emmanuel lesaffre statistician |
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| thomas lesaffre researcher |
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| jacques-françois-joseph lesaffre architect, FR |
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| lise lesaffre researcher |
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