Family name Khanyisa (Khanyisa 
) , worldwide, is a rare cognomen. The surname Khanyisa is characteristic of South Africa, where it is a rare surname, and the United States, where it is an extremely rare surname. Much more prevalently, Khanyisa is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Khanyisa | Germany, South Africa, Norway, United Kingdom, United States |
Booi, Qamata, Mashaba, Mashele, Mabunda, Mhlanga, Mhlongo, Sithole, Khanyie, Dlamini, Nombewu, Ngobeni, Manganyi, Maluleke, Madikane, Makhanya, Makhanyi, Rikhotso, Ngamlana, Mathebula, Makhubela, Makhubele, Ndlovu, Chabalala, Jacobs, Khanya, Diko, Jack, Feni, Mbali, Mnisi, Mzamo, Sambo, Bvuma, Khosa, Khoza, Klaas, Peter, Dyani, Dweba, Twani, Nkuna, Maneli, Mabasa, Mnyaka, Chauke, Baloyi, Khanyi, and Maswanganyi