Surname Upegui (Upegui 
) , across the world, is quite a common cognomen. The cognomen Upegui is habitual in Latin America and the Caribbean, particularly Colombia, where it is quite a common surname, Panama, where it is a rare surname, and Venezuela. Not in comparison with a country's population, it most frequently occurs in Colombia, the United States, and Venezuela. Much less frequently, Upegui is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Upegui | Panama, Colombia, Spain, Venezuela, United States |
| maría de jesús upegui Colombian catholic sister, CO (b. 1837) |
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| oscar upegui association football player, CO (b. 1969) |
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| cristian vargas upegui researcher |
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| yulieth upegui researcher (ORCID 0000-0002-9348-6227) |
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| erika upegui researcher |
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| carolina upegui Colombian cyclist, CO (b. 1989) |
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| alexánder arbey sánchez upegui |
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Mr, Ruth, Dany, Dora, Gina, Leon, Lina, Lilo, Lisa, Liza, Lore, Luis, Ludi, Jair, Jady, Jose, John, July, Juan, Jhon, Taty, Tori, Ruby, Tite, Rose, Kory, Ms, Jo, Ana, Liz, Lia, Luz, Joe, Mari, Mary, Mely, Mile, Mike, Sara, Alex, Alba, Agda, Aida, Aura, Caro, Cata, Bibi, Raul, and Nora