Surname Santobello (Santobello 
) , throughout the world, is a very rare family name. The cognomen Santobello is habitual in Italy, where it is a very rare surname, and the United States, where it is an extremely rare surname.
| VARIANT | COUNTRY |
|---|---|
| Santobello | Italy, United States |
| rudolph santobello American mobster (b. 1928) |
|