Last name Holthusen (Holthusen 
) , across the world, is a rare cognomen. The cognomen Holthusen is habitual in Germany, where it is a rare surname, New Zealand, and Switzerland. Measured by absolute frequency, it most frequently occurs in Germany, the United States, and Switzerland.
| VARIANT | COUNTRY |
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| Holthusen | Germany, Spain, New Zealand, United States, Switzerland |
| johannes holthusen (b. 1450) |
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| johannes holthusen DE (b. 1505) |
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| carl gustaf von holthusen (b. 1749) |
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gottfried friedrich heinrich august holthusen German politician (1848-1920), DE (b. 1848) |
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| gustav holthusen DE (b. 1848) |
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| wilhelm holthusen DE (b. 1874) |
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| georg holthusen (b. 1874) |
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| hermann holthusen German physician, DE (b. 1886) |
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| henry frank holthusen American lawyer, US (b. 1894) |
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| alma holthusen (b. 1892) |
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| agnes holthusen DE (b. 1896) |
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| hans egon holthusen German writer and academic, DE (b. 1913) |
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| inge holthusen (b. 1913) |
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| johannes holthusen German philologist (1924-1985), DE (b. 1924) |
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| wilhelm holthusen (b. 1923) |
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Mr, Kyle, Paul, Ruth, Ryan, Dale, Dawn, Dirk, Gary, Gabe, Gene, Glen, Lars, Lila, Lisa, Liam, Jack, Josh, John, Joan, Joey, Judy, Kirk, Beth, Barb, Cody, Ms, Ed, Max, Sue, Amy, Ron, Roy, Gab, Jan, Jon, Tobi, Tom, Wes, Mary, Mark, Meik, Sara, Sven, Anne, Anke, Cory, Cole, Ole, and Tina