Worldwide, Khanyisa (Khanyisa 
) is quite a rare largely girly, but seldom male first name. The first name Khanyisa is habitual in Sub-Saharan Africa, particularly South Africa, where it is quite a rare dominantly feminine, but uncommonly male name. Very seldom, Khanyisa is the last name as well as the forename.
| VARIANT | COUNTRY |
|---|---|
| Khanyisa | Germany, Norway, United Kingdom, South Africa, United States |
| khanyisa annelice sodidi researcher |
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| khanyisa chawane South African netball player, ZA (b. 1996) |
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| khanyisa mayo South African soccer player (b. 1998) |
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Booi, Qamata, Mashaba, Mashele, Mabunda, Mhlanga, Mhlongo, Sithole, Khanyie, Dlamini, Nombewu, Ngobeni, Manganyi, Maluleke, Madikane, Makhanya, Makhanyi, Rikhotso, Ngamlana, Mathebula, Makhubela, Makhubele, Ndlovu, Chabalala, Jacobs, Khanya, Diko, Jack, Feni, Mbali, Mnisi, Mzamo, Sambo, Bvuma, Khosa, Khoza, Klaas, Peter, Dyani, Dweba, Twani, Nkuna, Maneli, Mabasa, Mnyaka, Chauke, Baloyi, Khanyi, and Maswanganyi